The risk that disease-causing agents will develop resistance to antimicrobials increases whenever these precious medicines are overused or used inappropriately. Antimicrobial resistance is a threat to the health and welfare of humans and animals, whether aquatic or terrestrial. Continued availability and efficacy of existing antimicrobial classes are essential. Handling these invaluable medicines responsibly and prudently according to intergovernmental OIE Standards will help maintain their efficacy and availability for both human and animal health.