The European Joint Action on Antimicrobial Resistance and Healthcare-Associated Infections (EU-JAMRAI) is committed to several pivotal objectives aimed at enhancing the collective response to antimicrobial resistance (AMR) within Member States (MS) and Associated Countries (AC). Central to this mission is the provision of direct and substantial support to assist MS/AC in developing and updating their National Action Plans (NAPs) on AMR. Through targeted assistance programs, EU-JAMRAI seeks to facilitate the implementation of state-of-the-art Infection Prevention and Control (IPC) measures for both community-acquired and healthcare-associated infections, as well as Antimicrobial Stewardship (AMS) strategies across diverse settings. Moreover, the initiative endeavors to fortify the responsiveness and coordination of health systems within the Union by establishing and executing a comprehensive support program tailored to the needs of MS/AC. This includes supporting the development and implementation of core elements and competencies for AMS and IPC across various healthcare settings, thereby ensuring a unified and effective approach to protecting individuals from the threat of AMR throughout Europe.